Kinase-STAT Signaling and Potentiate the Antitumor Effects of IFN- in a Murine Model of Malignant Melanoma
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منابع مشابه
The Jak-Stat Signaling Pathway of Interferons System: Snapshots
Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...
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Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...
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Constitutive activation of Janus kinases (JAKs) and signal transducers and activators of transcription (STAT) occurs at very high frequency in various hematopoietic malignancies and solid tumors. It has been demonstrated that the tyrosine kinase inhibitor, AG-490, selectively blocks JAK activity and completely eliminates leukemia cells in a severe combined immunodeficient (SCID) mouse model. Be...
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IFN-a2b has been used to treat patients with malignant melanoma who are at high risk for recurrence after surgical resection. However, its exact mechanism of action is unknown. I hypothesized that IFN-a exerts a direct effect on the melanoma cell via the activation of signal transducer and activator of transcription (STAT) proteins. Cell lysates from melanoma cell lines and patient tumor sample...
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تاریخ انتشار 2004